First
Cloned Mammal
A
group of British researchers, headed by Dr. Ian Wilmut, an embryologist
at the Roslin Institute in Edinburgh, created a lamb using DNA from
an adult sheep. Dr. Wilmut
took a mammary cell from an adult sheep and prepared its DNA so
it would
be accepted by an egg from another sheep. He then removed the egg's
own DNA, replacing it with the DNA from the adult sheep by fusing
the egg with the adult cell. The fused cells, carrying the adult
DNA, began to grow and divide, just like a perfectly normal fertilized
egg, to form an embryo. The embryo was implanted into another ewe
and Dolly was born. DNA tests show that Dolly is the clone of the
adult ewe who supplied her DNA.
"What
this will mostly be used for is to produce more health-care products,"
says Wilmut. "It will enable us to study genetic diseases for which
there is presently no cure and track down the mechanisms that are
involved. The next step is to use the cells in culture in the lab
and target genetic changes into that culture."
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